Coronary artery disease Case Study No.9 (Pathology)

Coronary artery disease is the topic of this case study file no. 9. We try to discover the reason for this disease and how can we analyze it by using pathology techniques. So now we move to our main topic.

Coronary artery disease Case:

A 50 years old male is a bank officer who feels the sudden onset of severe constricting chest pain while attending a meeting in his office. He gives a history of intermittent pain over the sternum earlier too almost once a week which would go away when he sits down. He has mild hypertension, for which he is on dietary therapy. He also gives a family history of diabetes. His cholesterol level is elevated. He is not a smoker.


1. You are required to Discuss the clinical correlation with the pathogenesis of the features.

2. What is the probable diagnosis?

3. Investigate and confirm the diagnosis?

Clinical Correlation

This middle-aged executive having acute chest pain has several high-risk factors for coronary artery disease—history of hypertension, family history of diabetes mellitus, hypercholesterolaemia, stressful type of job and his age. This is further supported by the history of intermittent chest pain in the past which improved with rest, which was apparently due to angina. It may also be noted that on dietary therapy, and thus he is not being monitored for hypertension. However, another risk factor, smoking, is absent.

Probable Diagnosis

Coronary artery disease (acute myocardial infarction)


Here is how you can investigate Multiple myeloma through Clinical pathology

  1. ECG
  2. Biochemical estimation: Serum cardiac markers (CK-MB2: CK-MB1 ratio, LDH-1: LDH2 ratio, cardiac troponins T and I), renal function tests (urea, creatinine, BUN), liver function tests (bilirubin, ALT, AST, alkaline phosphatase, total proteins and AG ratio), lipid profile, blood glucose, electrolytes.
  3. CBC (haemoglobin, counts, indices), ESR, PCV, blood smear examination.
  4. Urine examination (albumin, glucose, microscopy).
  5. X-ray chest.
  6. Ultrasound examination of the abdomen.

Reference: Harsh Mohan Pathology

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